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How CBD Works in the Body



So you’ve read about the uses and benefits of CBD, but what exactly does it do to our bodies for us to feel its effects?


Whether you’re a regular CBD user or are seeking to try it, it’s important to stay informed on what you consume to ensure you make educated decisions. We’re here to help you do that. Let’s dive into how CBD works in the body.


The Endocannabinoid System (ECS)


Before we get into the details, let’s talk about the system that plays a central role in activating CBD compounds—the endocannabinoid system (ECS).


The ECS consists of neurotransmitters and receptor cells that run throughout our tissues. Though research on ECS is still ongoing, the biological system has been found to activate receptors that may help our bodies achieve homeostasis (regulating mood, appetite, sleep, and memory).


The ECS produces its own cannabinoids and holds a lock-and-key interaction with plant-derived cannabinoids that enter the body. When we take CBD, it binds with our ECS and activates different receptors, working to help restore balance within our bodies.


How long CBD stays in your body depends on the person (everyone’s bodies are different), but it typically stays in your system for two to five days. However, you will only feel the effects for two to three hours.


What Does CBD Do to the Body?


You can think of the ECS as an umbrella system that executes a flow-control mechanism—it binds with receptors found in our central and peripheral nervous systems. These receptors play different roles in regulating our bodies; one might play a role in managing sleep, while another might influence pain management.


Listed below are the common benefits people experience from using CBD; each comes with information on what CBD does to the body to produce its unique effects.


1. Decreased Anxiety & Depression


The most common benefits people report from taking CBD are a sense of calmness and reduced anxiety and depression. Studies have specifically shown CBD can be a potential treatment option for those who have anxiety disorders.


What Happens in the Body


CBD can activate 5-HT1A receptors located in the brain. 5-HT1A is a serotonin receptor that can help stabilize our mood and fuel feelings of well-being and happiness. This is perhaps the main reason why individuals use CBD to regulate their anxiety and depression.


In one study, individuals who experienced panic disorders were found to have impaired 5-HT1A receptors. Moreover, mice without 5-HT1A receptors demonstrated increased anxiety behaviors.


2. Better Sleep




Lower anxiety levels can promote a better night’s sleep. According to the American Sleep Association (ASA), CBD may decrease insomnia, helping you catch up on much-needed sleep. Adults who took CBD in one study reported improved sleep scores.


What Happens in the Body


5-HT1A receptors also play a role in sleep. When activated, these receptors may increase slow-wave sleep or REM sleep. REM is vital in refreshing and restoring your brain to perform at its best during the day.


3. Reduced Pain


CBD can activate receptors that offer anti-inflammatory properties. This activation may reduce chronic pain and provide relief for those who have arthritis.

What Happens in the Body

CBD has been shown to activate the following receptors:

  • TRPV1: TRPV1 receptors regulate pain, inflammation, and body temperature. Other cannabinoids such as CBG and CBN have also been known to activate TRPV1.

  • Glycine: Glycine plays an important role in pain sensation. It’s located in the spinal cord, brainstem, and retina.

4. Better Skin


CBD has been known to help alleviate blemishes and give you clearer skin. Our skin carries cannabinoid receptors, which is why you’ll see many brands offer CBD creams and lotions.


What Happens in the Body


Studies have shown evidence that cannabinoid receptors in our skin come from members of the transient receptor potential (TRP) ion channel family. TRP is located in our plasma membranes. They are involved in various types of sensory reception and ion homeostasis.


These cannabinoid receptors help:

  • Promote epidermal balance

  • Treat hair follicles and sebaceous glands

  • Soothe inflammation

The same studies linked above have shown the potential for these cannabinoid receptors to moderate dermatitis. When you lather CBD cream onto your skin, it activates TRP.


Choose Zeng Naturals for Your CBD Needs




Not all CBD is created equal, which is why it’s important to browse through different options before making a purchase. At Zeng Naturals, we cater to everyone’s CBD needs with our three lines:

Start browsing today to find the right CBD product for you and your loved one.

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